Possessing a weak constitution, the bespectacled Marie has spent a lot of time in the hospital due to her illness. Her pet Michael, a Golden Retriever, acts as her guardian and friend when her brother isn't around. She addresses her brother as Aniue-sama (兄上様), the honorific -uesama (a combination of ue and -sama) being used within the royal family or as a sign of politeness. In English, she calls him "Brother Mine". [from Wikipedia]