ToHeart2的故事情节是发生在《To Heart》一代的两年之后的同一所高中里，几乎所有的角色都是新登场的，只有姬百合姐妹在上一代的相关动画《To Heart ~Remember My Memories~》中登场过。

A song drifted in, carried by the cold wind’s embrace— It matched the guitar I played in the music room steeped in twilight. It echoed the piano someone played in the room next door. And then, from the rooftop, a voice rang out. High and clear, like the chiming of bells, weaving the three scattered melodies into one. It all began in late autumn. When someone fell in love. We were all giving our everything. We were all pressing forward, driven by feelings we couldn't hold back. We were all earnest, unwavering, and honest. In that fleeting moment, our hearts were bound, and we created memories that could never be replaced. But because of that, someone fell in love. A love that came too late. A love that should never have been. Then came winter—covering all sins beneath the endless snow. Then came spring—laying judgment bare as the snow melted away. [Translated from [url=https://web.archive.org/web/20180922102306/http://dlsoft.dmm.co.jp/detail/aquap_0019/]DMM[/url]]

純愛、憶えていますか？

１９９８ 冬。 音楽祭から一年後、森川由綺は再び音楽祭にノミネートされます。 あなた（プレイヤー）は由綺となって、音楽祭の１週間前からストーリーを進めます。 音楽祭の結果は？ 冬弥との愛の結末は？ それは、あなたの目でお確かめください。